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Contraindicated (one)pentobarbital will lessen the level or impact of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with robust CYP3A4 inducers will not be recommendedpentobarbital will minimize the level or effect of lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Con